PMID- 10571475
DA - 19991202
DCOM- 19991202
LR - 20001218
IS - 0735-7044
VI - 113
IP - 5
DP - 1999 Oct
TI - The hippocampus is not necessary for a place response but may be necessary for pliancy.
PG - 914-24 AB - Rats with kainate-colchicine hippocampal lesions (HL) and controls (C) were initially trained in the Morris water maze with procedures that deterred their prepotent thigmotaxic response. Training began with an escape platform that occupied nearly the entire pool. The area to which the rats could escape was made smaller by substituting smaller platforms as training progressed. In contrast to standard procedures, HL rats and C rats showed comparable performance during acquisition and preferentially searched the goal quadrant on probe trials during which the platform was removed. In a follow-up experiment, the platform was moved to a random position along the wall, which required a switch to a thigmotaxic response for most effective escape. HL rats that were thigmotaxic before place training did not switch to a thigmotaxic response as readily as did controls, behavior consistent with the view that hippocampal damage reduces pliancy.
AD - Department of Psychology and Institute for Neuroscience, University of
Texas at Austin, 78712, USA.
FAU - Day, L B
AU - Day LB
FAU - Weisand, M
AU - Weisand M
FAU - Sutherland, R J
AU - Sutherland RJ
FAU - Schallert, T
AU - Schallert T
LA - eng
PT - Journal Article
CY - UNITED STATES
TA - Behav Neurosci
JID - 8302411
RN - 0 (Excitatory Amino Acid Agonists)
RN - 0 (Toxins)
RN - 487-79-6 (Kainic Acid)
RN - 64-86-8 (Colchicine)
SB - IM
MH - Animal
MH - Colchicine
MH - Excitatory Amino Acid Agonists
MH - Hippocampus/drug effects/*physiology
MH - Kainic Acid
MH - Male
MH - Maze Learning/*physiology
MH - Rats
MH - Rats, Long-Evans
MH - Reaction Time/*physiology
MH - Toxins
EDAT- 1999/11/26
MHDA- 1999/11/26 00:01
PST - ppublish
SO - Behav Neurosci 1999 Oct;113(5):914-24.