PMID- 11528238
DA - 20010830
DCOM- 20011204
IS - 0028-2766
VI - 89
IP - 1
DP - 2001 Sep
TI - Biochemical, histological and behavioral consequences of nephrectomy in young and aged mice.
PG - 90-100 AB - BACKGROUND: This study investigates the effect of nephrectomy in young and aged mice on some biochemical, histological and behavioural aspects. METHODS: Each age group, 2- and 12-months-old, comprised a sham-operated group, a unilaterally nephrectomized group and a subtotally nephrectomized group. Consequences of nephrectomy were examined 10 days postsurgery on urea and guanidino compound levels in body fluids and brain; the remaining kidney by light-microscopic examination; and learning and memory abilities using the Morris water maze task. RESULTS: Effect of nephrectomy on urea and guanidino compound levels in plasma, urine and brain was significantly more pronounced in the young age group. Some guanidino compounds show a tendency to decrease with aging in the sham-operated group and the two nephrectomized groups. Higher compensatory kidney hypertrophy was found in younger nephrectomized mice whereas in older mice glomerular mesangial expansion was a common feature. Finally, young mice with subtotal nephrectomy displayed a slight but significant impairment in memory and learning; whilst old nephrectomized mice manifested no impairment. CONCLUSIONS: Nephrectomy induces more changes in younger mice than in older mice as observed in higher variation of urea and guanidino compound levels, glomerular volume and kidney hypertrophy and decline in spatial learning and memory. CI - Copyright 2001 S. Karger AG, Basel
AD - Department of Medecine-UIA, Laboratory of Neurochemistry and Behaviour at
the Born-Bunge Foundation, University of Antwerp, Universiteitsplein 1,
B-2610 Antwerp, Belgium.
FAU - Al Banchaabouchi, M
AU - Al Banchaabouchi M
FAU - Marescau, B
AU - Marescau B
FAU - D'Hooge, R
AU - D'Hooge R
FAU - Van Marck, E
AU - Van Marck E
FAU - De Deyn, P P
AU - De Deyn PP
LA - eng
PT - Journal Article
CY - Switzerland
TA - Nephron
JID - 0331777
RN - 0 (Guanidines)
RN - 57-13-6 (Urea)
SB - IM
MH - Age Factors
MH - Animal
MH - Brain Chemistry
MH - Guanidines/analysis/*blood/urine
MH - Hypertrophy
MH - Kidney/*pathology/surgery
MH - Kidney Glomerulus/pathology
MH - Male
MH - *Maze Learning
MH - Memory
MH - Mice
MH - Mice, Inbred C57BL
MH - *Nephrectomy
MH - Support, Non-U.S. Gov't
MH - Urea/analysis/blood/urine
EDAT- 2001/08/31 10:00
MHDA- 2002/01/05 10:01
AID - nef89090 [pii]
URLF- http://www.online.karger.com/library/karger/renderer/dataset.exe?jcode=NEF
&action=render&rendertype=fulltext&uid=NEF.nef89090
URLS- http://www.karger.com/journals/nef/nef_jh.htm
PST - ppublish
SO - Nephron 2001 Sep;89(1):90-100.