PMID- 11543772
DA - 20010906
DCOM- 20011101
IS - 0028-3908
VI - 41
IP - 4
DP - 2001 Sep
TI - RS 67333 and D-cycloserine accelerate learning acquisition in the rat.
PG - 517-22 AB - Various 5-hydroxytryptamine (5-HT) central receptor subtypes have been implicated in cognitive performances. In the present investigation, we studied the effects of the selective 5-HT(4) receptor agonist RS 67333 (1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-n-butyl-4-piperidinyl)-1-propan one; 1 mg/kg, i.p.) on spatial learning in the rat, and compared them to those of a reference drug, the partial NMDA receptor agonist D-cycloserine (10 mg/kg, i.p.). The effects of these two drugs were evaluated in four protocols which employed the Morris water maze task with various numbers of daily trials and inter-trial intervals (ITI; 4 trials with 30 s ITI; 2 trials with 2 h or 12 h ITI; or one daily trial). In the 2 trial-2 h ITI protocol, rats treated with RS 67333 or D-cycloserine exhibit a reduced mean swim distance during the first days of training when compared to controls. Neither RS 67333 nor D-cycloserine modified the acquisition performances in the 2 trial-12 h ITI or the one daily trial tests or the retention score measured in each protocol. These data suggest that RS 67333 and D-cycloserine can improve the learning rate in a high demand memory task and confirm that selective 5-HT(4) receptor ligands may provide novel approaches for the development of cognitive enhancers.
AD - Universite de Caen, Laboratoire de Pharmacologie, Centre d'Etudes et de
Recherche sur le Medicament de Normandie, UFR des Sciences
Pharmaceutiques, 1 rue Vaubenard, 14032 Caen Cedex, France.
FAU - Lelong, V
AU - Lelong V
FAU - Dauphin, F
AU - Dauphin F
FAU - Boulouard, M
AU - Boulouard M
LA - eng
PT - Journal Article
CY - England
TA - Neuropharmacology
JID - 0236217
RN - 0 (Aniline Compounds)
RN - 0 (Antimetabolites)
RN - 0 (Piperidines)
RN - 0 (Receptors, Glycine)
RN - 0 (Receptors, N-Methyl-D-Aspartate)
RN - 0 (Serotonin Agonists)
RN - 160845-95-4 (RS 67333)
RN - 68-41-7 (Cycloserine)
SB - IM
MH - Aniline Compounds/*pharmacology
MH - Animal
MH - Antimetabolites/*pharmacology
MH - Cycloserine/*pharmacology
MH - Male
MH - Maze Learning/*drug effects
MH - Piperidines/*pharmacology
MH - Rats
MH - Rats, Sprague-Dawley
MH - Receptors, Glycine/drug effects
MH - Receptors, N-Methyl-D-Aspartate/agonists
MH - Serotonin Agonists/*pharmacology
MH - Stimulation, Chemical
MH - Support, Non-U.S. Gov't
EDAT- 2001/09/07 10:00
MHDA- 2001/11/03 10:01
AID - S0028390801000855 [pii]
PST - ppublish
SO - Neuropharmacology 2001 Sep;41(4):517-22.