PMID- 11549742
DA - 20010910
DCOM- 20011004
IS - 1529-2401
VI - 21
IP - 18
DP - 2001 Sep 15
TI - The conjoint importance of the hippocampus and anterior thalamic nuclei for allocentric spatial learning: evidence from a disconnection study in the rat.
PG - 7323-30 AB - A disconnection procedure was used to test whether the hippocampus and anterior thalamic nuclei form functional components of the same spatial memory system. Unilateral excitotoxic lesions were placed in the anterior thalamic (AT) nuclei and hippocampus (HPC) in either the same (AT-HPC Ipsi group) or contralateral (AT-HPC Contra group) hemispheres of rats. The behavioral effects of these combined lesions were compared in several spatial memory tasks sensitive to bilateral hippocampal lesions. In all of the tasks tested, T-maze alternation, radial arm maze, and Morris water maze, those animals with lesions placed in the contralateral hemispheres were more impaired than those animals with lesions in the same hemisphere. These results provide direct support for the notion that the performance of tasks that require spatial memory rely on the operation of the anterior thalamus and hippocampus within an integrated neural network.
AD - School of Psychology, University of Cardiff, Wales CF10 3YG, United
[emd]
FAU - Warburton, E C
AU - Warburton EC
FAU - Baird, A
AU - Baird A
FAU - Morgan, A
AU - Morgan A
FAU - Muir, J L
AU - Muir JL
FAU - Aggleton, J P
AU - Aggleton JP
LA - eng
PT - Journal Article
CY - United States
TA - J Neurosci
JID - 8102140
RN - 6384-92-5 (N-Methylaspartate)
SB - IM
MH - Animal
MH - Anterior Thalamic Nuclei/pathology/*physiology
MH - Behavior, Animal/physiology
MH - Brain Injuries/chemically induced/pathology
MH - Hippocampus/pathology/*physiology
MH - Laterality/physiology
MH - Male
MH - Maze Learning/*physiology
MH - Memory/*physiology
MH - Microinjections
MH - N-Methylaspartate
MH - Nerve Net/physiology
MH - Rats
MH - Space Perception/*physiology
MH - Support, Non-U.S. Gov't
EDAT- 2001/09/11 10:00
MHDA- 2001/10/05 10:01
AID - 21/18/7323 [pii]
URLF- http://www.jneurosci.org/cgi/content/full/21/18/7323
URLS- http://www.jneurosci.org/cgi/content/abstract/21/18/7323
PST - ppublish
SO - J Neurosci 2001 Sep 15;21(18):7323-30.