PMID- 11584926
DA - 20011004
DCOM- 20020204
IS - 0735-7044
VI - 115
IP - 5
DP - 2001 Oct
TI - Behavioral characterization of dopamine D5 receptor null mutant mice.
PG - 1129-44 AB - To study behavioral functions of the D5 subtype, mice were generated with null mutations in the D5 gene. This 1st behavioral characterization of D5 null mutant mice (D5-/-) indicated normal general health, sensory abilities, and neurological reflexes. Under basal conditions, D5-/- mice were generally normal on locomotor activity, the rotarod test, acoustic startle response, prepulse inhibition, elevated plus-maze, light <--> dark exploration, Morris water maze, and cued and contextual fear conditioning. In the Porsolt forced swim test for antidepressant activity, male D5-/- mice showed lower levels of immobility. D5-/- mice showed some evidence of reduced responses to the hyperactivity-inducing effects of the D1/D5 receptor agonist SKF 81297. The ability of SKF 81297 to disrupt acoustic startle and prepulse inhibition appeared to be attenuated in D5-/- mice. These results suggest that the D5 receptor is not essential for many dopamine-mediated behaviors but may contribute to the pharmacological activation of dopaminergic pathways relevant to exploratory locomotion, startle, and prepulse inhibition.
AD - Section on Behavioral Genomics, National Institute of Mental Health,
National Institutes of Health, Bethesda, Maryland 20892-1375, USA.
[emd]
FAU - Holmes, A
AU - Holmes A
FAU - Hollon, T R
AU - Hollon TR
FAU - Gleason, T C
AU - Gleason TC
FAU - Liu, Z
AU - Liu Z
FAU - Dreiling, J
AU - Dreiling J
FAU - Sibley, D R
AU - Sibley DR
FAU - Crawley, J N
AU - Crawley JN
LA - eng
PT - Journal Article
CY - United States
TA - Behav Neurosci
JID - 8302411
RN - 0 (Receptors, Dopamine D1)
RN - 137750-35-7 (dopamine D5 receptor)
SB - IM
MH - Animal
MH - Arousal/genetics/physiology
MH - Behavior, Animal/*physiology
MH - Brain/physiology
MH - Exploratory Behavior/physiology
MH - Female
MH - Locomotion/physiology
MH - Male
MH - Maze Learning/physiology
MH - Mice
MH - Mice, Knockout
MH - Mice, Neurologic Mutants
MH - Motivation
MH - Neural Inhibition/physiology
MH - Receptors, Dopamine D1/*genetics/physiology
MH - Startle Reaction/physiology
MH - Support, U.S. Gov't, P.H.S.
EDAT- 2001/10/05 10:00
MHDA- 2001/10/05 10:00
PST - ppublish
SO - Behav Neurosci 2001 Oct;115(5):1129-44.