PMID- 11595347
DA - 20011011
DCOM- 20020115
IS - 0304-3940
VI - 312
IP - 2
DP - 2001 Oct 19
TI - Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss.
PG - 113-7 AB - Rat pups age of 14 postnatal day (P14) were subjected to lithium-pilocarpine (Li-PC) model of status epilepticus (SE). Control rats (n=6) were given an equivalent volume of saline intraperitoneally. Behavioral testing began on P60 including the Morris water maze, the radial arm maze, and the rotarod test. Brain were then analyzed with cresyl violet stain for histological lesions and evaluated for mossy fiber sprouting with the Timm stain. We observed spatial memory deficits both in the Morris water maze and radial arm maze in Li-PC-treated rat. There was no motor impairment in Li-PC-treated rat by the rotarod test. Two of six Li-PC-treated rats showed cell loss in hippocampal CA1 subfield. The Timm staining pattern was similar in both control and Li-PC-treated rats. Result of this study suggests that Li-PC-induced SE in immature rats cause long-term cognitive deficit and permanent cell loss in hippocampal CA1, but spare motor impairment.
AD - Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
FAU - Wu, C L
AU - Wu CL
FAU - Huang, L T
AU - Huang LT
FAU - Liou, C W
AU - Liou CW
FAU - Wang, T J
AU - Wang TJ
FAU - Tung, Y R
AU - Tung YR
FAU - Hsu, H Y
AU - Hsu HY
FAU - Lai, M C
AU - Lai MC
LA - eng
PT - Journal Article
CY - Ireland
TA - Neurosci Lett
JID - 7600130
RN - 0 (Muscarinic Agonists)
RN - 7439-93-2 (Lithium)
RN - 92-13-7 (Pilocarpine)
SB - IM
MH - Aging/*drug effects/physiology
MH - Animal
MH - Disease Models, Animal
MH - Epilepsy, Temporal Lobe/*pathology/physiopathology
MH - Female
MH - Hippocampus/*growth & development/pathology/physiopathology
MH - Lithium/pharmacology
MH - Male
MH - Maze Learning/*drug effects/physiology
MH - Memory Disorders/chemically induced/*pathology/physiopathology
MH - Motor Activity/drug effects/physiology
MH - Movement Disorders/etiology/pathology/physiopathology
MH - Muscarinic Agonists/pharmacology
MH - Nerve Degeneration/chemically induced/*pathology/physiopathology
MH - Neurons/drug effects/pathology
MH - Pilocarpine/pharmacology
MH - Rats
MH - Rats, Sprague-Dawley
MH - Status Epilepticus/chemically induced/*pathology/physiopathology
MH - Support, Non-U.S. Gov't
EDAT- 2001/10/12 10:00
MHDA- 2002/01/16 10:01
AID - S0304394001022029 [pii]
PST - ppublish
SO - Neurosci Lett 2001 Oct 19;312(2):113-7.