PMID- 11640934
DA - 20011019
DCOM- 20020110
IS - 0028-3908
VI - 41
IP - 6
DP - 2001 Nov
TI - Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1).
PG - 791-800 AB - Previous results have suggested that the Ras signaling pathway is involved in learning and memory. Ras is activated by nucleotide exchange factors, such as the calmodulin-activated guanine-nucleotide releasing factor 1 (Ras-GRF1). To test whether Ras-GRF1 is required for learning and memory, we inactivated the Ras-GRF1 gene in mice. These mutants performed normally in a rota-rod motor coordination task, and in two amygdala-dependent tasks (inhibitory avoidance and contextual conditioning). In contrast the mutants were impaired in three hippocampus-dependent learning tasks: contextual discrimination, the social transmission of food preferences, and the hidden-platform version of the Morris water maze. These studies indicate that Ras-GRF1 plays a role in hippocampal-dependent learning and memory.
AD - Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
FAU - Giese, K P
AU - Giese KP
FAU - Friedman, E
AU - Friedman E
FAU - Telliez, J B
AU - Telliez JB
FAU - Fedorov, N B
AU - Fedorov NB
FAU - Wines, M
AU - Wines M
FAU - Feig, L A
AU - Feig LA
FAU - Silva, A J
AU - Silva AJ
LA - eng
ID - NS38480/NS/NINDS
PT - Journal Article
CY - England
TA - Neuropharmacology
JID - 0236217
RN - 0 (ras-GRF1)
SB - IM
MH - Amygdala/physiology
MH - Animal
MH - Avoidance Learning/physiology
MH - Conditioning (Psychology)/physiology
MH - Crosses, Genetic
MH - Female
MH - Food Preferences/physiology
MH - Hippocampus/*physiology
MH - Learning/*physiology
MH - Male
MH - Maze Learning/physiology
MH - Memory/*physiology
MH - Mice
MH - Mice, Inbred C57BL
MH - Mice, Knockout
MH - Motor Activity/genetics
MH - Social Behavior
MH - Support, Non-U.S. Gov't
MH - Support, U.S. Gov't, P.H.S.
MH - ras-GRF1/*deficiency/genetics/*physiology
EDAT- 2001/10/20 10:00
MHDA- 2002/01/11 10:01
AID - S002839080100096X [pii]
PST - ppublish
SO - Neuropharmacology 2001 Nov;41(6):791-800.