PMID- 11682110
DA - 20011029
DCOM- 20020122
IS - 0166-4328
VI - 125
IP - 1-2
DP - 2001 Nov 1
TI - Phenotyping complex behaviours: assessment of circadian control and 5-choice serial reaction learning in the mouse.
PG - 189-93 AB - Currently, the behavioural phenotyping of mutant strains is restricted by the paucity of tests for the cognitive capabilities of mice. Most of the paradigms at present available such as the water maze or passive avoidance are dependent upon an aversive component for conditioning and as a consequence the data can often be confounded by the non-specific effects of stress. The development of mutant or transgenic mouse models of human diseases that effect cognitive function will require this confound to be overcome. Here we highlight the value of using two apparently different paradigms, one exploring circadian control and the other visuospatial attention. The first provides an example of an elicited behaviour while the second requires learning; neither is aversive in nature. Interestingly, the data from each strengthens the interpretation of both.
AD - Department of Neuroscience, Fujisawa Institute of Neuroscience, University
[emd]
FAU - Marston, H M
AU - Marston HM
FAU - Spratt, C
AU - Spratt C
FAU - Kelly, J S
AU - Kelly JS
LA - eng
PT - Journal Article
CY - Netherlands
TA - Behav Brain Res
JID - 8004872
SB - IM
MH - Animal
MH - Attention/physiology
MH - Brain/physiology
MH - Choice Behavior/*physiology
MH - Circadian Rhythm/*physiology
MH - Mice
MH - Mice, Inbred Strains
MH - Mice, Neurologic Mutants
MH - Orientation/physiology
MH - *Phenotype
MH - Reaction Time/genetics
MH - Serial Learning/*physiology
MH - Species Specificity
MH - Visual Perception/physiology
EDAT- 2001/10/30 10:00
MHDA- 2002/01/23 10:01
AID - S016643280100300X [pii]
PST - ppublish
SO - Behav Brain Res 2001 Nov 1;125(1-2):189-93.