PMID- 11682146
DA - 20011029
DCOM- 20020130
IS - 0304-3940
VI - 313
IP - 3
DP - 2001 Nov 9
TI - Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils.
PG - 137-40 AB - The protective effects of huperzine A on transient global ischemia in gerbils were investigated. Five min of global ischemia in gerbils results in working memory impairments shown by increased escape latency in a water maze and reduced time spent in the target quadrant. These signs of dysfunction are accompanied by delayed degeneration of pyramidal hippocampal CA1 neurons and by decrease in acetylcholinesterase activity in the hippocampus. Subchronic oral administration of huperzine A (0.1 mg/kg, twice per day for 14 days) after ischemia significantly reduced the memory impairment, reduced neuronal degeneration in the CA1 region, and partially restored hippocampal choline acetyltransferase activity. The ability of huperzine A to attenuate memory deficits and neuronal damage after ischemia might be beneficial in cerebrovascular type dementia.
AD - State Key Laboratory of Drug Research, Shanghai Institute of Materia
Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of
Sciences, 294 Tai-yuan Road, 200031, Shanghai, People's Republic of China.
FAU - Zhou, J
AU - Zhou J
FAU - Zhang, H Y
AU - Zhang HY
FAU - Tang, X C
AU - Tang XC
LA - eng
PT - Journal Article
CY - Ireland
TA - Neurosci Lett
JID - 7600130
RN - 0 (Sesquiterpenes)
RN - 102518-79-6 (huperzine A)
RN - EC 2.3.1.6 (Choline O-Acetyltransferase)
RN - EC 3.1.1.7 (Acetylcholinesterase)
SB - IM
MH - Acetylcholinesterase/metabolism
MH - Administration, Oral
MH - Animal
MH - Choline O-Acetyltransferase/metabolism
MH - Cognition Disorders/*drug therapy/etiology/pathology
MH - Disease Models, Animal
MH - Drug Evaluation, Preclinical
MH - Enzyme Activation/drug effects
MH - Gerbillinae
MH - Hippocampus/*drug effects/pathology/physiopathology
MH - Ischemic Attack, Transient/complications/*drug therapy/physiopathology
MH - Memory Disorders/drug therapy/etiology/pathology
MH - Neurons/*drug effects/metabolism/pathology
MH - Reaction Time/drug effects
MH - Sesquiterpenes/*administration & dosage
MH - Support, Non-U.S. Gov't
EDAT- 2001/10/30 10:00
MHDA- 2002/01/31 10:01
AID - S0304394001022650 [pii]
PST - ppublish
SO - Neurosci Lett 2001 Nov 9;313(3):137-40.