PMID- 11684332
DA - 20011030
DCOM- 20011218
IS - 0304-3940
VI - 313
IP - 1-2
DP - 2001 Nov 2
TI - Cerebral serotonin depletion induces egocentric learning improvement in developing rats.
PG - 29-32 AB - Egocentric learning ability of developing serotonin (5-HT)-depleted female rats was evaluated in the Morris maze test. 5-HT depletion was accomplished by a unique intracisternal injection of 5,7-dihydroxytriptamine at 21 days-old. A first behavioral test was applied before the lesion procedure. The animals were thereafter challenged to resolve the same test at 40 and 60 days-old. 5-HT depletion caused a dual effect on the rats' egocentric learning ability, i.e. at 40 days; control rats learned the task while the experimental rats were unable to learn it. At 60 days, control animals were unable to learn the test, while the experimental rats showed a successful performance. These results strongly suggest that 5-HT neurotransmission is necessary for egocentric learning establishment and regulation.
AD - Laboratorio de Psicobiologia, Centro de Investigacion Biomedica de
Michoacan, Instituto Mexicano del Seguro Social, A.P. 7-70; C.P. 58261,
[emd]
FAU - Olvera-Cortes, E
AU - Olvera-Cortes E
FAU - Barajas-Perez, M
AU - Barajas-Perez M
FAU - Morales-Villagran, A
AU - Morales-Villagran A
FAU - Gonzalez-Burgos, I
AU - Gonzalez-Burgos I
LA - eng
PT - Journal Article
CY - Ireland
TA - Neurosci Lett
JID - 7600130
RN - 0 (Serotonin Agents)
RN - 31363-74-3 (5,7-Dihydroxytryptamine)
RN - 50-67-9 (Serotonin)
SB - IM
MH - 5,7-Dihydroxytryptamine/pharmacology
MH - Age Factors
MH - Animal
MH - Brain/*growth & development/*metabolism
MH - Female
MH - Maze Learning/drug effects/*physiology
MH - Memory/physiology
MH - Rats
MH - Rats, Sprague-Dawley
MH - Serotonin/*metabolism
MH - Serotonin Agents/pharmacology
MH - Space Perception/physiology
EDAT- 2001/10/31 10:00
MHDA- 2002/01/05 10:01
AID - S0304394001022327 [pii]
PST - ppublish
SO - Neurosci Lett 2001 Nov 2;313(1-2):29-32.