PMID- 11694624
DA - 20011105
DCOM- 20011211
IS - 0022-3166
VI - 131
IP - 11
DP - 2001 Nov
TI - Oral administration of soybean lecithin transphosphatidylated phosphatidylserine improves memory impairment in aged rats.
PG - 2951-6 AB - Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) was prepared from soybean lecithin and L-serine by a transphosphatidylation reaction, and its effect on age-related memory impairment was evaluated in rats by the Morris water maze test. Continuous oral administration of SB-tPS (60 mg x kg(-1) x d(-1) for 60 d) to male aged rats (24-25 mo) significantly improved performance in the water maze escape test (P < 0.01 vs. control aged rats) similar to bovine brain cortex-derived phosphatidylserine, which restores cognitive function in patients with senile dementia. SB-tPS also increased acetylcholine release and the Na(+), K(+)-ATPase activity of the synaptosomes prepared from these aged rats to the level in young rats. The nootropic actions of SB-tPS in the present study can be partly explained by the changes in these biochemical activities.
AD - Yakult Central Institute for Microbiological Research, 1796 Yaho,
Kunitachi, Tokyo 186-8650, Japan.
FAU - Suzuki, S
AU - Suzuki S
FAU - Yamatoya, H
AU - Yamatoya H
FAU - Sakai, M
AU - Sakai M
FAU - Kataoka, A
AU - Kataoka A
FAU - Furushiro, M
AU - Furushiro M
FAU - Kudo, S
AU - Kudo S
LA - eng
PT - Journal Article
CY - United States
TA - J Nutr
JID - 0404243
RN - 0 (Phosphatidylserines)
RN - 0 (Phospholipids)
RN - 51-84-3 (Acetylcholine)
RN - 57-88-5 (Cholesterol)
RN - EC 3.6.1.37 (Na(+)-K(+)-Exchanging ATPase)
SB - IM
MH - Acetylcholine/metabolism
MH - Administration, Oral
MH - Animal
MH - Brain/*drug effects/enzymology/metabolism
MH - Cholesterol/metabolism
MH - Escape Reaction/drug effects
MH - Male
MH - Memory Disorders/*drug therapy
MH - Na(+)-K(+)-Exchanging ATPase/metabolism
MH - Phosphatidylserines/administration & dosage/*therapeutic use
MH - Phospholipids/metabolism
MH - Rats
MH - Rats, Wistar
MH - Soybeans
EDAT- 2001/11/06 10:00
MHDA- 2002/01/05 10:01
URLF- http://www.nutrition.org/cgi/content/full/131/11/2951
URLS- http://www.nutrition.org/cgi/content/abstract/131/11/2951
PST - ppublish
SO - J Nutr 2001 Nov;131(11):2951-6.