PMID- 11711252
DA - 20011116
DCOM- 20020201
IS - 0892-0362
VI - 23
IP - 5
DP - 2001 Sep-Oct
TI - Developmental lead exposure: behavioral alterations in the short and long term.
PG - 489-95 AB - Wistar dams were exposed to 500 ppm of Pb, as Pb acetate, or 660 ppm Na acetate in drinking water during pregnancy and lactation. Male pups at 23 (weaned) or 70 days (adult) of age were submitted to behavioral evaluation and Pb determination. The behaviors evaluated were: locomotor activity (open-field test), motor coordination (rotarod test), exploratory behavior (holeboard test), anxiety (elevated plus maze and social interaction tests), and learning and memory (shuttle box). Pb levels were measured in the blood and cerebral regions (hippocampus and striatum) of dams and pups. The results of the present report demonstrated that exposure to Pb during pregnancy and lactation induces in weaned pups hyperactivity, decreased exploratory behavior, and impairment of learning and memory. These alterations were observed at blood Pb levels in the range that may be attained in children chronically exposed to low levels of Pb (21+/-3 microg/dl). Regarding adults, the results demonstrated that the regimen of exposure adopted induces anxiety in these animals at nondetectable blood Pb levels.
AD - Center for Toxicological Assistance, University Estadual Paulista,
[emd]
FAU - Moreira, E G
AU - Moreira EG
FAU - Vassilieff, I
AU - Vassilieff I
FAU - Vassilieff, V S
AU - Vassilieff VS
LA - eng
PT - Journal Article
CY - United States
TA - Neurotoxicol Teratol
JID - 8709538
RN - 0 (Organometallic Compounds)
RN - 301-04-2 (lead acetate)
RN - 7439-92-1 (Lead)
SB - IM
MH - Aging/*physiology
MH - Animal
MH - Anxiety/chemically induced
MH - Body Weight/drug effects
MH - Brain/metabolism
MH - Exploratory Behavior/drug effects
MH - Feeding Behavior/drug effects
MH - Female
MH - Lactation
MH - Lead/blood/pharmacokinetics/*toxicity
MH - Motor Activity/drug effects
MH - Organometallic Compounds/blood/pharmacokinetics/*toxicity
MH - Pregnancy
MH - *Prenatal Exposure Delayed Effects
MH - Psychomotor Performance/drug effects
MH - Rats
MH - Rats, Wistar
MH - Support, Non-U.S. Gov't
MH - Time Factors
MH - Water Supply
EDAT- 2001/11/17 10:00
MHDA- 2002/02/02 10:01
AID - S0892036201001593 [pii]
PST - ppublish
SO - Neurotoxicol Teratol 2001 Sep-Oct;23(5):489-95.