PMID- 11713467
DA - 20011127
DCOM- 20020111
IS - 1097-6256
VI - 4
IP - 12
DP - 2001 Dec
TI - Memory retrieval impairment induced by hippocampal CA3 lesions is blocked by adrenocortical suppression.
PG - 1169-71 AB - There is evidence that in rats, partial hippocampal lesions or selective ablation of the CA3 subfield can disrupt retrieval of spatial memory and that hippocampal damage disinhibits hypothalamic-pituitary-adrenocortical (HPA)-axis activity, thereby elevating plasma levels of adrenocorticotropin and corticosterone. Here we report evidence that attenuation of CA3 lesion-induced increases in circulating corticosterone levels with the synthesis inhibitor metyrapone, administered shortly before water-maze retention testing, blocks the impairing effects of the lesion on memory retrieval. These findings suggest that elevated adrenocortical activity is critical in mediating memory retrieval deficits induced by hippocampal damage.
AD - Center for the Neurobiology of Learning and Memory, and Department of
Neurobiology and Behavior, University of California, Irvine, California
[emd]
FAU - Roozendaal, B
AU - Roozendaal B
FAU - Phillips, R G
AU - Phillips RG
FAU - Power, A E
AU - Power AE
FAU - Brooke, S M
AU - Brooke SM
FAU - Sapolsky, R M
AU - Sapolsky RM
FAU - McGaugh, J L
AU - McGaugh JL
LA - eng
ID - MH12526/MH/NIMH
ID - RO1 MH53814/MH/NIMH
PT - Journal Article
CY - United States
TA - Nat Neurosci
JID - 9809671
RN - 0 (Pyridines)
RN - 17286-92-9 (metapyrone)
RN - 487-79-6 (Kainic Acid)
RN - 50-22-6 (Corticosterone)
SB - IM
MH - Adrenal Cortex/drug effects/metabolism/*secretion
MH - Animal
MH - Corticosterone/antagonists & inhibitors/metabolism/*secretion
MH - Hippocampus/injuries/*physiopathology/surgery
MH - Hypothalamo-Hypophyseal System/*physiopathology
MH - Kainic Acid
MH - Male
MH - Maze Learning/drug effects/physiology
MH - Memory/physiology
MH - Memory Disorders/drug therapy/etiology/*physiopathology
MH - Nerve Degeneration/chemically induced/physiopathology
MH - Neural Inhibition/drug effects/*physiology
MH - Neural Pathways/injuries/physiopathology/surgery
MH - Pituitary-Adrenal System/drug effects/*physiopathology
MH - Pyridines/pharmacology
MH - Rats
MH - Rats, Sprague-Dawley
MH - Reaction Time/drug effects/physiology
MH - Support, Non-U.S. Gov't
MH - Support, U.S. Gov't, P.H.S.
EDAT- 2001/11/20 10:00
MHDA- 2002/01/12 10:01
AID - 10.1038/nn766 [doi]
AID - nn766 [pii]
PST - ppublish
SO - Nat Neurosci 2001 Dec;4(12):1169-71.