PMID- 11715074
DA - 20011120
DCOM- 20020111
IS - 0014-4819
VI - 141
IP - 3
DP - 2001 Dec
TI - Contextual fear conditioning is disrupted by lesions of the subcortical, but not entorhinal, connections to the hippocampus.
PG - 304-11 AB - Recent studies have questioned the importance of the entorhinal cortex (ERC) for normal hippocampal function. For example, fibre-sparing ERC lesions have been found to have no effect on spatial learning in the watermaze. There is also doubt as to the importance of the ERC for contextual fear conditioning, with previous studies having yielded conflicting results. In an attempt to resolve this issue, the present study compared aspiration and cytotoxic ERC lesioned rats, along with fimbria-fornix (FFX) lesioned animals and sham operated controls, on an unsignalled contextual fear conditioning paradigm. The results of the present study show that whereas lesions of the FFX disrupted contextual freezing, neither aspiration nor cytotoxic ERC lesions had any effect on this behaviour. Aspiration ERC lesioned rats, however, like FFX lesioned animals, did display hyperactivity prior to the delivery of footshock. These results suggest that whereas projections between the hippocampus and subcortical structures are important for normal levels of contextual freezing, projections from the entorhinal cortex are not essential.
AD - Department of Experimental Psychology, University of Oxford, South Parks
[emd]
FAU - Bannerman, D M
AU - Bannerman DM
FAU - Yee, B K
AU - Yee BK
FAU - Lemaire, M
AU - Lemaire M
FAU - Jarrard, L
AU - Jarrard L
FAU - Iversen, S D
AU - Iversen SD
FAU - Rawlins, J N
AU - Rawlins JN
FAU - Good, M A
AU - Good MA
LA - eng
PT - Journal Article
CY - Germany
TA - Exp Brain Res
JID - 0043312
SB - IM
MH - Animal
MH - Behavior, Animal/physiology
MH - Brain Mapping
MH - Cerebral Cortex/*physiology
MH - *Conditioning (Psychology)/*physiology
MH - Entorhinal Cortex/*physiology
MH - Fear/*physiology
MH - Fornix (Brain)/physiology
MH - Hippocampus/*physiology
MH - Male
MH - Neural Pathways/physiology
MH - Rats
MH - Rats, Inbred Strains
MH - Support, Non-U.S. Gov't
EDAT- 2001/11/21 10:00
MHDA- 2002/01/12 10:01
PHST- 2001/Mar/08 [received]
PHST- 2001/Jul/23 [accepted]
AID - 10.1007/s002210100869 [doi]
PST - ppublish
SO - Exp Brain Res 2001 Dec;141(3):304-11.