PMID- 11720766
DA - 20011126
DCOM- 20020128
IS - 0304-3940
VI - 316
IP - 1
DP - 2001 Dec 4
TI - Grafting neural stem cells improved the impaired spatial recognition in ischemic rats.
PG - 9-12 AB - To determine the possible therapeutic potential of neural stem cells (NSCs) introduced into the damaged central nervous system, we grafted adult hippocampus-derived NSCs into the hippocampus of rats with transient global ischemia. Transient four-vessel occlusion yielded 90-95% losses of pyramidal neurons in the hippocampal CA1 region. In this region, 1-3% of the grafted cells survived; and 3-9% of them expressed NeuN, a neuronal marker. Rats with more than 120 NeuN-positive cells showed partial improvement of impaired spatial learning in a water maze test. These results suggest that NSCs grafted in the ischemic brain are able to differentiate into neurons and to improve spatial recognition.
AD - Department of Neurosurgery, Clinical Neuroscience, Kyoto University
Graduate School of Medicine, Sakyo-ku, Kyoto, 606-8507, Japan.
FAU - Toda, H
AU - Toda H
FAU - Takahashi, J
AU - Takahashi J
FAU - Iwakami, N
AU - Iwakami N
FAU - Kimura, T
AU - Kimura T
FAU - Hoki, S
AU - Hoki S
FAU - Mozumi-Kitamura, K
AU - Mozumi-Kitamura K
FAU - Ono, S
AU - Ono S
FAU - Hashimoto, N
AU - Hashimoto N
LA - eng
PT - Journal Article
CY - Ireland
TA - Neurosci Lett
JID - 7600130
SB - IM
MH - Animal
MH - Brain Ischemia/pathology/physiopathology/*surgery
MH - Brain Tissue Transplantation/*methods
MH - Cell Differentiation/physiology
MH - Cell Transplantation/methods
MH - Hippocampus/cytology/physiology/*transplantation
MH - Male
MH - *Maze Learning/physiology
MH - Neurons/cytology/physiology/*transplantation
MH - Rats
MH - Rats, Inbred F344
MH - *Recognition (Psychology)/physiology
MH - Stem Cells/cytology/physiology/*transplantation
MH - Support, Non-U.S. Gov't
EDAT- 2001/11/27 10:00
MHDA- 2002/01/29 10:01
AID - S030439400102331X [pii]
PST - ppublish
SO - Neurosci Lett 2001 Dec 4;316(1):9-12.