PMID- 11728429
DA - 20011130
DCOM- 20020108
IS - 0014-2999
VI - 431
IP - 2
DP - 2001 Nov 16
TI - Beneficial effect of the sigma(1) receptor agonist PRE-084 against the spatial learning deficits in aged rats.
PG - 223-7 AB - Sigma(1) (sigma(1)) receptor agonists showed anti-amnesic properties in pharmacological amnesia models. We now investigated whether the selective sigma(1) receptor agonist, 2-(4-morpholinoethyl)-1-phenylcyclohexane-1-carboxylate hydrochloride (PRE-084), could ameliorate spatial learning in aged animals, using a water-maze procedure. Wistar rats, 3 or 24 months old, were trained to locate a visible platform and then an invisible platform. Finally, a transfer test was performed during saline or PRE-084 treatment. Aged, but not adult, animals showed learning deficits unrelated to visual impairments. The PRE-084 treatment allowed aged animals to learn the new platform location, in terms of decreased latencies to the platform during training and increased presence in the quadrant during retention. The results of these experiments suggest a potential of selective sigma(1) receptor agonists as cognitive enhancers during ageing.
AD - Behavioural Neuropharmacology Group, INSERM U.336, Institut de Biologie,
4, blvd Henri IV, 34060 Montpellier, France.
[emd]
FAU - Maurice, T
AU - Maurice T
LA - eng
PT - Journal Article
CY - Netherlands
TA - Eur J Pharmacol
JID - 1254354
RN - 0 (Morpholines)
RN - 0 (Receptors, sigma)
RN - 138847-85-5 (2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate)
SB - IM
MH - Aging/*physiology
MH - Animal
MH - Cognition/drug effects
MH - Learning Disorders/*drug therapy/physiopathology
MH - Male
MH - Morpholines/*pharmacology
MH - Rats
MH - Rats, Wistar
MH - Receptors, sigma/*agonists
EDAT- 2001/12/01 10:00
MHDA- 2002/01/10 10:01
AID - S0014299901014364 [pii]
PST - ppublish
SO - Eur J Pharmacol 2001 Nov 16;431(2):223-7.