PMID- 11745324
DA - 20011217
DCOM- 20020125
IS - 0012-1630
VI - 39
IP - 4
DP - 2001 Dec
TI - Effects of ectopias and their cortical location on several measures of learning in BXSB mice.
PG - 286-300 AB - About half of BXSB/MpJ-Yaa mice have ectopias, which are misplaced clusters of neurons located in layer I of cortex. This study replicated several previous findings showing that there are learning differences between mice with ectopias and those without. In addition, we had sufficient numbers of ectopic mice to investigate if ectopics learned differently depending on the cortical location of the ectopia(s). Mice with at least one ectopia located in prefrontal cortex were initially impaired in learning the Morris maze, as well as relearning the Lashley maze when it was inverted, but learned better in the radial-arm maze when compared to ectopic mice with ectopias located in nonprefrontal regions of cortex. Mice with at least one ectopia in motor cortex learned the Lashley maze better than mice with ectopias located outside motor cortex. In sum, the cortical location of the ectopia(s) affected learning performance in certain tasks within the ectopic group, but regardless of the cortical location of the ectopia(s), ectopics still learned differently than nonectopics in several tasks. CI - Copyright 2001 John Wiley & Sons, Inc.
AD - Biobehavioral Sciences Graduate Degree Program, University of Connecticut,
Storrs, CT 06269, USA.
FAU - Hyde, L A
AU - Hyde LA
FAU - Hoplight, B J
AU - Hoplight BJ
FAU - Harding, S
AU - Harding S
FAU - Sherman, G F
AU - Sherman GF
FAU - Mobraaten, L E
AU - Mobraaten LE
FAU - Denenberg, V H
AU - Denenberg VH
LA - eng
ID - HD 20806/HD/NICHD
PT - Journal Article
CY - United States
TA - Dev Psychobiol
JID - 0164074
SB - IM
MH - Animal
MH - Brain Mapping
MH - Cerebral Cortex/*pathology
MH - Choristoma/*pathology
MH - Female
MH - Male
MH - Maze Learning/*physiology
MH - Mice
MH - Mice, Neurologic Mutants
MH - *Neurons
MH - Orientation/*physiology
MH - Recall/*physiology
MH - Retention (Psychology)/physiology
MH - Support, U.S. Gov't, P.H.S.
EDAT- 2001/12/18 10:00
MHDA- 2002/01/26 10:01
AID - 10.1002/dev.1006 [pii]
PST - ppublish
SO - Dev Psychobiol 2001 Dec;39(4):286-300.