PMID- 11749083
DA - 20011225
IS - 1074-7427
VI - 77
IP - 1
DP - 2002 Jan
TI - The Effects of l-Glucose on Memory in Mice Are Modulated by Peripherally Acting Cholinergic Drugs.
PG - 17-28 AB - d-Glucose improves memory in animals and humans and in subjects with memory pathologies. To date, the accepted conclusion drawn from animal research is that d-glucose improves memory via alterations in central cholinergic systems. However, recent evidence suggests that a sugar which does not cross the blood-brain barrier also facilitates memory (Talley, Arankowsky-Sandoval, McCarty, & Gold, 1999). The present study examined the effects of peripherally administered l-glucose, a stereoisomer of d-glucose, in male mice. Intraperitoneal administration of l-glucose (300 mg/kg) before testing enhanced place learning in the Morris water maze. Mice injected with l-glucose had significantly shorter escape latencies than mice injected with saline (1 ml/kg). Effects were observed on both reference memory and working memory tasks. l-Glucose did not facilitate performance on either task when it was simultaneously administered with cholinergic antagonists that are excluded from the central nervous system. Thus, simultaneous administration of either methyl-scopolamine (0.3 mg/kg), a peripherally acting muscarinic receptor blocker, or hexamethonium (1 mg/kg), a peripherally acting nicotinic receptor blocker, reversed the effect of l-glucose on memory. These findings suggest that the memory effects of l-glucose may be mediated by facilitated acetylcholine synthesis and/or release in the peripheral nervous system. CI - Copyright 2002 Elsevier Science.
AD - Department of Psychology, Macquarie University, Sydney, 2109, Australia
FAU - Lawson, Catherine J
AU - Lawson CJ
FAU - Homewood, Judi
AU - Homewood J
FAU - Taylor, Alan J
AU - Taylor AJ
LA - eng
PT - Journal Article
CY - United States
TA - Neurobiol Learn Mem
JID - 9508166
SB - IM
EDAT- 2001/12/26 10:00
MHDA- 2001/12/26 10:00
AID - 10.1006/nlme.2000.4001 [doi]
AID - nlme.2000.4001 [pii]
PST - ppublish
SO - Neurobiol Learn Mem 2002 Jan;77(1):17-28.