PMID- 11749859
DA - 20011224
IS - 0253-9756
VI - 22
IP - 9
DP - 2001 Sep
TI - Improvement of melatonin to the learning and memory impairment induced by amyloid bgr;-peptide 25-35 in elder rats.
PG - 797-803 AB - AIM: To investigate improvement of melatonin on learning and memory impairment induced by amyloid bgr;-peptide 25-35 (Abgr;(25-35)) in elder rats. METHODS: Step-down type passive avoidance test, shuttle-box test, and Morris water maze were used together to determine effects of Abgr;(25-35) and melatonin on learning and memory. Pathological changes were observed by HE, Congo red, and Ag staining. RESULTS: The elder rats were injected bilaterally Abgr;(25-35) 20 mgr;g into the hippocampus to induce learning and memory dysfunction. Melatonin administration (0.1, 1, and 10 mg/kg, ig[inverted exclamation mark]A8 d) to the Abgr;(25-35)-treated rats prolonged the latency, shortened the total stimulating time, and decreased the number of errors in the step-down test. Suttle-box test showed that melatonin improved amnesic rats' performace at the same doses. Melatonin (0.1, 1, and 10 mg/kg ), giving for 10 d, could enhance the spatial resolution of amnesic rats in Morris water maze test. Also in Abgr;(25-35)-treated group, a decrease in the number of neurons in cortex and hippocampus, a massive glial reaction, and neurophilic phenomenon were detected by HE staining; the positive vascular amyloidosis by Congo red and fibrils by Ag staining were observed. Melatonin (0.1 and 1 mg/kg)could inhibit above pathological changes in Abgr;(25-35) group. CONCLUSION: Melatonin improved the impaired learning and memory induced by Abgr;(25-35) in elder rats.
AD - Institute of Clinical Pharmacology, Anhui Medical University, Hefei
[emd]
AU - Shen YX
AU - Wei W
AU - Yang J
AU - Liu C
AU - Dong C
AU - Xu SY
LA - ENG
PT - JOURNAL ARTICLE
TA - Acta Pharmacol Sin
JC - DPS
JID - 100956087
EDAT- 2001/12/26 10:00
MHDA- 2001/12/26 10:00
PST - ppublish
SO - Acta Pharmacol Sin 2001 Sep;22(9):797-803.