PMID- 11809497
DA - 20020125
IS - 0166-4328
VI - 129
IP - 1-2
DP - 2002 Feb 1
TI - Improvement of spatial memory by (R)-alpha-methylhistamine, a histamine H(3)-receptor agonist, on the Morris water-maze in rat.
PG - 77-82 AB - This work aims to clarify the role of histamine in learning and memory. This is done by studying the effect of administration of the histamine precursor, L-histidine (His), and the agonist of the H(3) receptor (R)-alpha-methylhistamine (RAMH), on acquisition and retention of spatial reference memory in rats. Treatment with RAMH (10 mg/kg i.p.) facilitates recovery of spatial memory. In contrast, administration of His (500 mg/kg i.p.) does not affect the performance of this task. Moreover, pharmacological modulation of the cerebral histaminergic system does not impair the animal's behavioral flexibility, i.e. their ability to adapt to a new learning task in the same stimular context. Improved retention of spatial memory after a reduction in cerebral histamine confirms the modulating role of this neurotransmitter in memory processes.
AD - Laboratory of Psychobiology, Faculty of Psychology, Oviedo, Plaza Feijoo
s/n, E-33003, Oviedo, Spain
FAU - Rubio, S
AU - Rubio S
FAU - Begega, A
AU - Begega A
FAU - Santin, L J
AU - Santin LJ
FAU - Arias, J L
AU - Arias JL
LA - eng
PT - Journal Article
CY - Netherlands
TA - Behav Brain Res
JID - 8004872
SB - IM
EDAT- 2002/01/26 10:00
MHDA- 2002/01/26 10:00
AID - S016643280100328X [pii]
PST - ppublish
SO - Behav Brain Res 2002 Feb 1;129(1-2):77-82.