PMID- 11817511
DA - 20020130
IS - 0278-5846
VI - 26
IP - 2
DP - 2002 Feb
TI - SR 141716A prevents delta9-tetrahydrocannabinol-induced spatial learning deficit in a Morris-type water maze in mice.
PG - 321-5 AB - This study reports a series of spatial discrimination procedures in a Morris-type maze to investigate the effects of delta9-tetrahydrocannabinol (delta9-THC) on different phases of learning and memory in mice. Adult male mice were given training trails to find the submerged platform at a fixed location in the water maze adapted for mice. In additional experiments, mice were trained with the repeated acquisition procedure to test the working memory. Results indicate that delta9-THC (8 mg/kg i.p.) 30 min pretest impaired specifically the acquisition of spatial learning and the performance of mice in the working memory task, while consolidation and retrieval of a previously learned task were not affected. There was no evidence of motoric difficulty, as the number of quadrant line crossings was not decreased and no visible sign of sensorimotor disturbance was observed during swimming. Pretreatment with SR 141716A (1 mg/kg i.p.), a CB1 cannabinoid receptor antagonist, significantly prevented the learning deficits in the water maze. These findings show that delta9-THC impairs spatial discrimination learning in a selective way in the water maze in mice and that these deficits may be mediated by cannabinoid receptors.
AD - Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade
Federal de Santa Catarina, Florianopolis, Brazil.
FAU - Da, SilvaGeorgeE
AU - Da S
FAU - Takahashi, Reinaldo N
AU - Takahashi RN
LA - eng
PT - Journal Article
CY - England
TA - Prog Neuropsychopharmacol Biol Psychiatry
JID - 8211617
SB - IM
EDAT- 2002/01/31 10:00
MHDA- 2002/01/31 10:00
PST - ppublish
SO - Prog Neuropsychopharmacol Biol Psychiatry 2002 Feb;26(2):321-5.