PMID- 9099820
DA - 19970902
DCOM- 19970902
LR - 20001218
IS - 0006-8993
VI - 751
IP - 2
DP - 1997 Mar 21
TI - Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE.
PG - 307-14 AB - Recent studies suggest that apolipoprotein E (apoE) might play a neurotrophic function in the central nervous system and that altered functioning of this molecule could result in neurodegeneration. The main objective of this study was to determine if neurodegenerative and cognitive alterations in apoE-deficient mice are reversible by infusion of recombinant apoE into the lateral ventricles. ApoE-deficient mice treated with either apoE3 or apoE4 showed a significant improvement in their learning capacity in the Morris water maze compared to saline-infused apoE-deficient mice. While this improved performance was associated with restoration of neuronal structure, the poor learning ability of apoE-deficient mice treated with saline correlated with the disrupted synapto-dendritic structure. This study supports the contention that apoE might play a neurotrophic effect in vivo and suggests that apoE might have a potential therapeutic role.
AD - University of California, San Diego, School of Medicine, Department of
Neurosciences, La Jolla 92093-0624, USA.
FAU - Masliah, E
AU - Masliah E
FAU - Samuel, W
AU - Samuel W
FAU - Veinbergs, I
AU - Veinbergs I
FAU - Mallory, M
AU - Mallory M
FAU - Mante, M
AU - Mante M
FAU - Saitoh, T
AU - Saitoh T
LA - eng
ID - AG05131/AG/NIA
ID - AG10689/AG/NIA
PT - Journal Article
CY - NETHERLANDS
TA - Brain Res
JID - 0045503
RN - 0 (Apolipoproteins E)
RN - 0 (Recombinant Proteins)
SB - IM
MH - Animal
MH - Apolipoproteins E/*deficiency/*pharmacology
MH - Cognition/drug effects
MH - Cognition Disorders/*psychology
MH - Dendrites/drug effects
MH - Injections, Intraventricular
MH - Isomerism
MH - Mice
MH - Mice, Inbred C57BL
MH - Mice, Mutant Strains
MH - Nerve Degeneration/*drug effects
MH - Recombinant Proteins
MH - Support, Non-U.S. Gov't
MH - Support, U.S. Gov't, P.H.S.
MH - Synapses/drug effects
EDAT- 1997/03/21
MHDA- 1997/03/21 00:01
AID - S0006899396014205 [pii]
PST - ppublish
SO - Brain Res 1997 Mar 21;751(2):307-14.