PMID- 9205792
DA - 19970904
DCOM- 19970904
LR - 20001218
IS - 0361-9230
VI - 43
IP - 1
DP - 1997
TI - Ameliorating effects of SDZ ENA 713 on age-associated decreases in learning performance and brain choline acetyltransferase activity in rats.
PG - 39-42 AB - In the present study, we have investigated the effects of SDZ ENA 713 on spatial learning deficits in aged rats. Using the same animals, the effect of SDZ ENA 713 on choline acetyltransferase was simultaneously studied to obtain a basis for the behavioral study. In the aged rats, the spatial learning and choline acetyltransferase activity in the frontal cortex were significantly deteriorated compared with young adult rats. SDZ ENA 713 (0.2 mg/kg) significantly shortened the time to reach a hidden platform without affecting swim rates in the water maze task. SDZ ENA 713 (0.1 and 0.2 mg/kg) inhibited aging-induced decreases in choline acetyltransferase activity in the frontal cortex. These results suggest that SDZ ENA 713 ameliorates aging-induced learning deficits and cholinergic dysfunction in rats.
AD - Sandoz Tsukuba Research Institute, Department of Pharmacology, Japan.
FAU - Ohara, T
AU - Ohara T
FAU - Fukaya, H
AU - Fukaya H
FAU - Itanaka, K
AU - Itanaka K
FAU - Seno, N
AU - Seno N
LA - eng
PT - Journal Article
CY - UNITED STATES
TA - Brain Res Bull
JID - 7605818
RN - 0 (Biological Markers)
RN - 0 (Carbamates)
RN - 0 (Cholinesterase Inhibitors)
RN - 0 (Receptors, Muscarinic)
RN - 123441-03-2 (rivastigmine)
RN - EC 2.3.1.6 (Choline O-Acetyltransferase)
SB - IM
MH - Aging/metabolism/*psychology
MH - Animal
MH - Biological Markers
MH - Brain/*drug effects/enzymology
MH - Carbamates/*pharmacology
MH - Choline O-Acetyltransferase/*antagonists & inhibitors
MH - Cholinesterase Inhibitors/*pharmacology
MH - Drug Evaluation, Preclinical
MH - Learning Disorders/*drug therapy
MH - Male
MH - Maze Learning/drug effects
MH - Rats
MH - Rats, Inbred F344
MH - Receptors, Muscarinic/drug effects/metabolism
EDAT- 1997/01/01
MHDA- 1997/01/01 00:01
AID - S0361923096003498 [pii]
PST - ppublish
SO - Brain Res Bull 1997;43(1):39-42.