PMID- 9858374
DA - 19990226
DCOM- 19990226
LR - 20010323
IS - 0959-4965
VI - 9
IP - 16
DP - 1998 Nov 16
TI - D-cycloserine, a partial NMDA receptor-associated glycine-B site agonist, enhances reversal learning, but a cholinesterase inhibitor and nicotine has no effect.
PG - 3647-51 AB - The present study examined the efficacy of single and combined treatments with an anticholinesterase, tetrahydroaminoacridine, nicotine and a glycine-B site partial agonist, D-cycloserine, in alleviating the water maze reversal learning defect induced by a medial septal lesion. D-cycloserine (3 and 10 mg/kg) improved reversal learning. Tetrahydroaminoacridine (1 and 3 mg/kg) and nicotine (0.1 and 0.3 mg/kg) had no effect on reversal learning. A combination of tetrahydroaminoacridine 3 mg/kg or nicotine 0.3 mg/kg and D-cycloserine 10 mg/kg was not more effective than D-cycloserine 10 mg/kg alone in improving reversal learning. This suggests that stimulation of NMDA mechanisms may more effectively improve in medial septal-lesioned rats reversal learning processes than stimulation of cholinergic activity.
AD - Department of Neurology, University of Kuopio, Finland.
FAU - Riekkinen, P Jr
AU - Riekkinen P Jr
FAU - Ikonen, S
AU - Ikonen S
FAU - Riekkinen, M
AU - Riekkinen M
LA - eng
PT - Journal Article
CY - ENGLAND
TA - Neuroreport
JID - 9100935
RN - 0 (Antimetabolites)
RN - 0 (Cholinesterase Inhibitors)
RN - 0 (Nicotinic Agonists)
RN - 0 (Receptors, N-Methyl-D-Aspartate)
RN - 321-64-2 (Tacrine)
RN - 54-11-5 (Nicotine)
RN - 56-40-6 (Glycine)
RN - 68-41-7 (Cycloserine)
SB - IM
MH - Alzheimer Disease/drug therapy
MH - Animal
MH - Antimetabolites/*pharmacology
MH - Binding Sites/physiology
MH - Cholinesterase Inhibitors/*pharmacology
MH - Conditioning (Psychology)/drug effects
MH - Cycloserine/*pharmacology
MH - Denervation
MH - Glycine/chemistry
MH - Maze Learning/drug effects
MH - Nicotine/*pharmacology
MH - Nicotinic Agonists/*pharmacology
MH - Rats
MH - Rats, Wistar
MH - Receptors, N-Methyl-D-Aspartate/chemistry/*physiology
MH - Reversal Learning/drug effects
MH - Septal Nuclei/chemistry/physiology/surgery
MH - Tacrine/*pharmacology
EDAT- 1998/12/19 03:02
MHDA- 2001/03/28 10:01
PST - ppublish
SO - Neuroreport 1998 Nov 16;9(16):3647-51.